Beta-blocker eyedrops and nocturnal arterial hypotension.

@article{Hayreh1999BetablockerEA,
  title={Beta-blocker eyedrops and nocturnal arterial hypotension.},
  author={S. S. Sohan Singh Hayreh and Patricia A Podhajsky and Miriam Bridget Zimmerman},
  journal={American journal of ophthalmology},
  year={1999},
  volume={128 3},
  pages={301-9}
}
PURPOSE To investigate the effects of topical beta-blocker eyedrops on nocturnal arterial hypotension and heart rate and on visual field deterioration. METHODS We prospectively investigated 275 white patients, 161 with glaucomatous optic neuropathy and 114 with nonarteritic anterior ischemic optic neuropathy, by 24-hour ambulatory blood pressure monitoring and diurnal curve of intraocular pressure, in addition to detailed ophthalmic evaluation. Of the patients with glaucomatous optic… CONTINUE READING

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Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Hourly average blood pressure data analyses showed overall a drop in blood pressure as well as heart rate during sleep , and a significantly greater drop in mean diastolic blood pressure ( P = .009 ) at night in normal - tension glaucoma than in anterior ischemic optic neuropathy .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Hourly average blood pressure data analyses showed overall a drop in blood pressure as well as heart rate during sleep , and a significantly greater drop in mean diastolic blood pressure ( P = .009 ) at night in normal - tension glaucoma than in anterior ischemic optic neuropathy .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
The findings of our studies , as well as those of others , suggest that any factor that increases nocturnal arterial hypotension is a potential risk factor in vulnerable individuals with glaucomatous optic neuropathy or anterior ischemic optic neuropathy .
The findings of our studies , as well as those of others , suggest that any factor that increases nocturnal arterial hypotension is a potential risk factor in vulnerable individuals with glaucomatous optic neuropathy or anterior ischemic optic neuropathy .
We prospectively investigated 275 white patients , 161 with glaucomatous optic neuropathy and 114 with nonarteritic anterior ischemic optic neuropathy , by 24-hour ambulatory blood pressure monitoring and diurnal curve of intraocular pressure , in addition to detailed ophthalmic evaluation .
We prospectively investigated 275 white patients , 161 with glaucomatous optic neuropathy and 114 with nonarteritic anterior ischemic optic neuropathy , by 24-hour ambulatory blood pressure monitoring and diurnal curve of intraocular pressure , in addition to detailed ophthalmic evaluation .
The findings of our studies , as well as those of others , suggest that any factor that increases nocturnal arterial hypotension is a potential risk factor in vulnerable individuals with glaucomatous optic neuropathy or anterior ischemic optic neuropathy .
The findings of our studies , as well as those of others , suggest that any factor that increases nocturnal arterial hypotension is a potential risk factor in vulnerable individuals with glaucomatous optic neuropathy or anterior ischemic optic neuropathy .
We prospectively investigated 275 white patients , 161 with glaucomatous optic neuropathy and 114 with nonarteritic anterior ischemic optic neuropathy , by 24-hour ambulatory blood pressure monitoring and diurnal curve of intraocular pressure , in addition to detailed ophthalmic evaluation .
We prospectively investigated 275 white patients , 161 with glaucomatous optic neuropathy and 114 with nonarteritic anterior ischemic optic neuropathy , by 24-hour ambulatory blood pressure monitoring and diurnal curve of intraocular pressure , in addition to detailed ophthalmic evaluation .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
Of the 275 patients , 114 were using topical beta - blocker eyedrops twice daily ( 76 with normal - tension glaucoma , 26 with primary open - angle glaucoma , and 12 with anterior ischemic optic neuropathy ) .
Of the patients with glaucomatous optic neuropathy , 131 had normal - tension glaucoma and 30 had primary open - angle glaucoma .
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