Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol.

@article{Capomolla2000BetablockadeTI,
  title={Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol.},
  author={Soccorso Capomolla and Oreste Febo and Marco Gnemmi and Giorgio Riccardi and Cristina Opasich and Angelo Caporotondi and Andrea Mortara and Gian Domenico Pinna and Franco Cobelli},
  journal={American heart journal},
  year={2000},
  volume={139 4},
  pages={596-608}
}
BACKGROUND In patients with chronic heart failure, the use of carvedilol therapy induces clinical and hemodynamic improvement. However, although the benefits of this beta-blocker have been established in patients with chronic heart failure, the mechanisms underlying them and the changes in left ventricular systolic function, diastolic function, and mitral regurgitation during long-term therapy remain unclear. OBJECTIVE To identify the clinical and functional effects of carvedilol, focusing on… CONTINUE READING
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