Beta-arrestins as regulators of signal termination and transduction: how do they determine what to scaffold?

@article{Defea2011BetaarrestinsAR,
  title={Beta-arrestins as regulators of signal termination and transduction: how do they determine what to scaffold?},
  author={Kathryn A Defea},
  journal={Cellular signalling},
  year={2011},
  volume={23 4},
  pages={621-9}
}
Over the last decade β-arrestins have emerged as pleiotropic scaffold proteins, capable of mediating numerous diverse responses to multiple agonists. Most well characterized are the G-protein-coupled receptor (GPCR) stimulated β-arrestin signals, which are sometimes synergistic with, and sometimes independent of, heterotrimeric G-protein signals. β-arrestin signaling involves the recruitment of downstream signaling moieties to β-arrestins; in many cases specific sites of interaction between… CONTINUE READING

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