Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

  title={Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.},
  author={H{\aa}vard Attramadal and Jeffrey L. Arriza and Chiye J Aoki and Ted M Dawson and Juan Codina and Madan Mohan Kwatra and Solomon H Snyder and Marc G. Caron and Robert J Lefkowitz},
  journal={The Journal of biological chemistry},
  volume={267 25},
Homologous or agonist-specific desensitization of beta 2-adrenergic receptors (beta 2AR) is mediated by the beta-adrenergic receptor kinase (beta ARK) which specifically phosphorylates the agonist-occupied form of the receptor. However, the capacity of beta ARK-phosphorylated beta 2AR to stimulate Gs in a reconstituted system is only minimally impaired. Recently, a protein termed beta-arrestin, was cloned from a bovine brain cDNA library and found to quench phosphorylated beta 2AR-coupling to… CONTINUE READING
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