Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

  title={Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.},
  author={Takahisa Noma and Anthony Lemaire and Sathyamangla V. Naga Prasad and Liza Barki-Harrington and Douglas G. Tilley and Juhsien Chen and Philippe Le Corvoisier and Jonathan D. Violin and Huijun Wei and Robert J Lefkowitz and Howard A Rockman},
  journal={The Journal of clinical investigation},
  volume={117 9},
Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors (betaARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl cyclase activation. Here, we identify a new signaling mechanism using both in vitro and in vivo systems whereby beta-arrestins mediate beta1AR signaling to the EGFR. This beta-arrestin-dependent transactivation of the EGFR, which is independent of G protein activation, requires the G… CONTINUE READING


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