Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.

  title={Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.},
  author={Sudarshan Rajagopal and Jihee Kim and Seungkirl Ahn and Stewart Craig and Christopher M. Lam and Norma P. Gerard and Craig Gerard and Robert J Lefkowitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 2},
Ubiquitously expressed seven-transmembrane receptors (7TMRs) classically signal through heterotrimeric G proteins and are commonly referred to as G protein-coupled receptors. It is now recognized that 7TMRs also signal through beta-arrestins, which act as versatile adapters controlling receptor signaling, desensitization, and trafficking. Most endogenous receptors appear to signal in a balanced fashion using both beta-arrestin and G protein-mediated pathways. Some 7TMRs are thought to be… CONTINUE READING
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