Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.

@article{Girnita2007BetaarrestinAM,
  title={Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.},
  author={L Girnita and Sudha K Shenoy and Bita Sehat and Radu Vasilcanu and Daiana Vasilcanu and A Girnita and Robert J Lefkowitz and Olle Larsson},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 15},
  pages={11329-38}
}
Beta-arrestin1, which regulates many aspects of seven transmembrane receptor (7TMR) biology, has also been shown to serve as an adaptor, which brings Mdm2, an E3 ubiquitin ligase to the insulin-like growth factor-1 receptor (IGF-1R), leading to its proteasome-dependent destruction. Here we demonstrate that IGF-1R stimulation also leads to ubiquitination of beta-arrestin1, which regulates vesicular trafficking and activation of ERK1/2. This beta-arrestin1-dependent ERK activity can occur even… CONTINUE READING
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