Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3ß pathways.

@article{Sun2010Betaarrestin2M,
  title={Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3\ss pathways.},
  author={Xiuli Sun and Yi Zhang and Jianliu Wang and Li-hui Wei and Hui Li and Gregory A. Hanley and Miaoqing Zhao and Yi Li and Deling Yin},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1800 9},
  pages={912-8}
}
BACKGROUND Resveratrol is emerging as a novel anticancer agent. However, the mechanism(s) by which resveratrol exerts its effects on endometrial cancer (EC) are unknown. We previously reported that beta-arrestin 2 plays a critical role in cell apoptosis. The role of ß-arrestin 2 in resveratrol modulation of endometrial cancer cell apoptosis remains to be established. SCOPE OF REVIEW EC cells HEC1B and Ishikawa were transfected with either ß-arrestin 2 RNA interfering (RNAi) plasmid or beta… CONTINUE READING