Beta-amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes: modulation of uptake as a survival mechanism.

@article{FernndezTom2004Betaamyloid2535IG,
  title={Beta-amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes: modulation of uptake as a survival mechanism.},
  author={Paz Fern{\'a}ndez-Tom{\'e} and Bego{\~n}a Brera and M. L. Arevalo and Maria L de Ceballos},
  journal={Neurobiology of disease},
  year={2004},
  volume={15 3},
  pages={580-9}
}
Glutamate transporters are vulnerable to oxidants resulting in reduced uptake function. We have studied the effects of beta-amyloid(25-35) (beta A(25-35)) on [(3)H]-glutamate uptake on cortical neuron or astrocyte cultures in comparison with a scrambled peptide (SCR) and dihydrokainic acid (DHK), a prototypic uptake inhibitor. beta A(25-35) was more potent than DHK in inhibiting glutamate uptake and the effects of both were more marked on astrocytes than on neurons. At 24 h, beta A(25-35) dose… CONTINUE READING

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