Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

Abstract

Beta amyloid (Aβ) peptides are the major constituents of the senile plaques present in Alzheimer's diseased brain. Pathogenesis has been associated with the aggregated form of the peptide as these fibrils are the conformation readily found in the plaques. However, recent studies have shown that the nonaggregated, soluble assemblies of Aβ have the potential… (More)
DOI: 10.1186/1742-2094-6-1

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