Beta-amyloid fragment potentiates IL-6 and TNF-alpha secretion by LPS in astrocytes but not in microglia.

@article{Forloni1997BetaamyloidFP,
  title={Beta-amyloid fragment potentiates IL-6 and TNF-alpha secretion by LPS in astrocytes but not in microglia.},
  author={Gianluigi Forloni and Fabio Mangiarotti and Nadia Angeretti and E. J. De Lucca and Maria-Grazia De Simoni},
  journal={Cytokine},
  year={1997},
  volume={9 10},
  pages={759-62}
}
The effect of a peptide homologous to the biologically active fragment of beta amyloid 25-35 (beta 25-35) was studied on interleukin 6 (IL-6) and tumour necrosis factor (TNF-alpha) secretion induced by lipopolysaccharide (LPS) in primary rat astrocytes and microglia. Twenty-four hour exposure to LPS (50 ng/ml) induced IL-6 and TNF-alpha both in astrocytes and in microglial cells, while the effect of beta 25-35 (50 microM) per se was negligible in both cell types. In microglial cells, the… CONTINUE READING

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