Beta-amyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy.

Abstract

Although amyloid beta-protein (A beta) has long been implicated in the pathogenesis of Alzheimer's disease, little is known about the mechanism by which A beta causes dementia. A beta leads to neuronal cell death in vivo and in vitro, but recent evidence suggests that the property of the amnesic characteristic of Alzheimer's disease can be explained by a… (More)

Topics

Cite this paper

@article{Ikegaya2002BetaamyloidEG, title={Beta-amyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy.}, author={Yuji Ikegaya and Sigeru Matsuura and Sayaka Ueno and Atsushi Baba and Maki Kobayashi Yamada and Nobuyoshi Nishiyama and Norio Matsuki}, journal={The Journal of biological chemistry}, year={2002}, volume={277 35}, pages={32180-6} }