Beta-amyloid 25 to 35 is intercalated in anionic and zwitterionic lipid membranes to different extents.

@article{Dante2002Betaamyloid2T,
  title={Beta-amyloid 25 to 35 is intercalated in anionic and zwitterionic lipid membranes to different extents.},
  author={Silvia Dante and Thomas Hau\ss and Norbert A. Dencher},
  journal={Biophysical journal},
  year={2002},
  volume={83 5},
  pages={2610-6}
}
Neuronal plasma membranes are thought to be the primary target of the neurotoxic beta-amyloid peptides (Abeta) in the pathogenesis of the Alzheimer's disease. Histologically, Abeta peptides are observed as extracellular macroscopic senile plaques, and most biophysical techniques have indicated the presence of Abeta close to the lipid headgroup region but not in the core of the membrane bilayers. The focus of this study is an investigation of the interaction between Abeta and lipid bilayers from… CONTINUE READING

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