Beta-amyloid (1-42) peptide impairs blood-brain barrier function after intracarotid infusion in rats.

@article{Jancs1998BetaamyloidP,
  title={Beta-amyloid (1-42) peptide impairs blood-brain barrier function after intracarotid infusion in rats.},
  author={G{\'a}bor Jancs{\'o} and Ferenc Domoki and P{\'e}ter S{\'a}ntha and J{\'a}nos Tam{\'a}s Varga and Jacqueline Fischer and Kate Orosz and Botond Penke and Attila Becskei and M{\'a}ria Dux and Louis Toth},
  journal={Neuroscience letters},
  year={1998},
  volume={253 2},
  pages={139-41}
}
The effects of intracarotid infusions of beta-amyloid (1-42) peptide was studied on the permeability of brain vessels. Using a quantitative Evans blue method a dose-dependent increase of brain tissue albumin content was established following intracarotid injections of the peptide. Cerebral vessels of increased permeability were also demonstrated with a vital 'staining' technique. Lectin histochemistry revealed an almost complete abolition of specific lectin binding sites of affected endothelial… CONTINUE READING
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