Beta-amino-thiols inhibit the zinc metallopeptidase activity of tetanus toxin light chain.

@article{Martin1998BetaaminothiolsIT,
  title={Beta-amino-thiols inhibit the zinc metallopeptidase activity of tetanus toxin light chain.},
  author={Lo{\"i}c Martin and F. Cornille and Pascale Coric and B. Roques and Marie-Claude Fourni{\'e}-Zaluski},
  journal={Journal of medicinal chemistry},
  year={1998},
  volume={41 18},
  pages={
          3450-60
        }
}
Tetanus neurotoxin is a 150-kDa protein produced by Clostridium tetani, which causes the lethal spastic paralytic syndromes of tetanus by blocking inhibitory neurotransmitter release at central synapses. The toxin light chain (50 kDa) has a zinc endopeptidase activity specific for synaptobrevin, an essential component of the neuroexocytosis apparatus. Previous unsuccessful attempts to block the proteolytic activity of this neurotoxin with well-known inhibitors of other zinc proteases led us to… CONTINUE READING
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