Beta-alanine potentiation of [3H]flunitrazepam binding to rat spinal cord homogenates.

  title={Beta-alanine potentiation of [3H]flunitrazepam binding to rat spinal cord homogenates.},
  author={Luis M. Orensanz and Carlos Cordoba and Inmaculada Fern{\'a}ndez},
  journal={Neuroscience letters},
  volume={111 3},
The effect of beta-alanine, gamma-aminobutyric acid (GABA), and other functionally related amino acids on [3H]flunitrazepam binding to rat spinal cord homogenates was studied. beta-Alanine potentiated [3H]flunitrazepam binding by 40% and GABA by 88%. Taurine increased the binding by 19%. Hypotaurine produced an 11% increase. No significant effect was seen in glycine, alanine, serine, valine or the dipeptide carnosine. The beta-alanine increase in [3H]flunitrazepam binding was completely… CONTINUE READING