Beta-adrenoreceptor agonism influences retinal responses to hypoxia in a model of retinopathy of prematurity.

@article{Monte2012BetaadrenoreceptorAI,
  title={Beta-adrenoreceptor agonism influences retinal responses to hypoxia in a model of retinopathy of prematurity.},
  author={Massimo Dal Monte and Davide Martini and Valentina Latina and Barbara Pavan and Luca Filippi and Paola Bagnoli},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 4},
  pages={2181-92}
}
PURPOSE In a mouse model of oxygen-induced retinopathy (OIR), a well-established model of retinopathy of prematurity (ROP), blocking beta-adrenoreceptors (β-ARs), and, in particular, β2-ARs, counteracts retinal responses to hypoxia. In the present work, we determined the effects of the β-AR agonist isoproterenol on retinal angiogenesis and β-AR signaling to better clarify the role of sympathetic transmission in ROP. METHODS Isoproterenol was administered subcutaneously. Protein kinase A… CONTINUE READING
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