Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells.

@article{Slotkin2000BetaadrenoceptorSA,
  title={Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells.},
  author={Theodore A. Slotkin and Jian Zhang and Ria D Dancel and Stephanie J. Garcia and Carrie Willis and Frederic J. Seidler},
  journal={Breast cancer research and treatment},
  year={2000},
  volume={60 2},
  pages={153-66}
}
MDA-MB-231 human breast cancer cells express high beta-adrenoceptor levels, predominantly the beta2 subtype. Receptor stimulation by isoproterenol evoked immediate reductions in DNA synthesis which were blocked completely by propranolol and were of the same magnitude as effects elicited by high concentrations of 8-Br-cAMP. Isoproterenol-induced inhibition of DNA synthesis was maintained throughout several days of exposure, resulting in a decrement in total cell number, and the effects were… CONTINUE READING