Beta-adrenoceptor selectivity of dobutamine: in vivo and in vitro studies.

  title={Beta-adrenoceptor selectivity of dobutamine: in vivo and in vitro studies.},
  author={C. Maccarrone and Errol Malta and Colin Raper},
  journal={Journal of cardiovascular pharmacology},
  volume={6 1},
We compared the beta-adrenoceptor stimulant actions of dobutamine and (-)-isoprenaline in isolated tissue preparations (atria, trachea, and uterus) from the guinea pig and in chloralose-anaesthetized, vagotomized cats (arterial blood pressure, heart rate, hindlimb perfusion pressure, and soleus muscle contractility). The results obtained in these experiments indicate that, on a dose basis, dobutamine shows little selectivity in producing alpha-, beta 1-, and beta 2-adrenoceptor-mediated effects… CONTINUE READING