Beta adrenoceptor interaction of full and partial agonists in the cat heart and soleus muscle.

@article{Hedberg1981BetaAI,
  title={Beta adrenoceptor interaction of full and partial agonists in the cat heart and soleus muscle.},
  author={Anders Hedberg and Hillevi Mattsson},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1981},
  volume={219 3},
  pages={798-808}
}
The effects of a nonselective (isoproterenol), a beta-1 selective (prenalterol) and a beta-2-selective (procaterol) agonist on beta adrenoceptor occupancy, adenylate cyclase activity and muscle contractions in the myocardium (beta-1) and soleus muscle (beta-2) of the reserpine-pretreated cat were investigated. Each compound fully inhibited the specific binding of [125I] iodohydroxybenzylpindolol in both tissues. Myocardial and soleus muscle adenylate cyclase were equipotently activated by… CONTINUE READING

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