Beta-adrenoceptor antagonist activities and binding affinities of timolol enantiomers in rat atria.

@article{Karhuvaara1989BetaadrenoceptorAA,
  title={Beta-adrenoceptor antagonist activities and binding affinities of timolol enantiomers in rat atria.},
  author={Sakari Karhuvaara and Timo J Kaila and Risto K. Huupponen},
  journal={The Journal of pharmacy and pharmacology},
  year={1989},
  volume={41 9},
  pages={
          649-50
        }
}
S-Timolol is an effective anti-glaucoma drug, but has potentially hazardous side effects. Recently, R-timolol, also, has been reported to be effective in lowering elevated intraocular pressure. In the present study, the beta-adrenoceptor antagonist activities and binding of R- and S-enantiomers of timolol have been examined on rat atrial preparations. The beta-antagonistic activities were investigated using spontaneously beating rat heart atria. Both timolol enantiomers inhibited… CONTINUE READING

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