Beta-adrenoceptor activation and PKA regulate delayed rectifier K+ channels of vascular smooth muscle cells.

@article{Aiello1998BetaadrenoceptorAA,
  title={Beta-adrenoceptor activation and PKA regulate delayed rectifier K+ channels of vascular smooth muscle cells.},
  author={Ernesto Alejandro Aiello and Andrew Todd Malcolm and M. P. Walsh and William C. Cole},
  journal={The American journal of physiology},
  year={1998},
  volume={275 2 Pt 2},
  pages={H448-59}
}
Macroscopic 4-aminopyridine (4-AP)-sensitive, delayed rectifier K+ current of vascular smooth muscle cells is increased during beta-adrenoceptor activation with isoproterenol via a signal transduction pathway involving adenylyl cyclase and cAMP-dependent protein kinase (PKA) (Aiello, E. A., M. P. Walsh, and W. C. Cole. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H926-H934, 1995.). In this study, we identified the single delayed rectifier K+ (KDR) channel(s) of rabbit portal vein myocytes… CONTINUE READING

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