Beta-adrenergic stimulation increases cAMP and melatonin production in ovine pinealocyte cultures.

@article{Howell1991BetaadrenergicSI,
  title={Beta-adrenergic stimulation increases cAMP and melatonin production in ovine pinealocyte cultures.},
  author={Heather Howell and P Jeffrey Morgan},
  journal={Journal of pineal research},
  year={1991},
  volume={10 3},
  pages={122-9}
}
An ovine pinealocyte suspension culture method, using glands from young sheep as a source of cells, has been developed to study mechanisms of pineal regulation in this species. Cell suspensions are obtained by enzymatic digestion (preliminary trypsinization followed by collagenase/pronase treatment) of pineal glands and these cells may be usefully retained in culture for up to 48 hr. Initial characterization of cyclic adenosine monophosphate and melatonin production responses to adrenergic… CONTINUE READING

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