Beta-adrenergic stimulation contributes to maintenance of endothelial barrier functions under baseline conditions.

@article{Spindler2011BetaadrenergicSC,
  title={Beta-adrenergic stimulation contributes to maintenance of endothelial barrier functions under baseline conditions.},
  author={Volker Spindler and Jens Waschke},
  journal={Microcirculation},
  year={2011},
  volume={18 2},
  pages={
          118-27
        }
}
OBJECTIVES cAMP signaling within the endothelium is known to reduce paracellular permeability and to protect against loss of barrier functions under various pathological conditions. Because activation of β-adrenergic receptors elevates cellular cAMP, we tested whether β-adrenergic receptor signaling contributes to the maintenance of baseline endothelial barrier properties. METHODS We compared hydraulic conductivity of rat postcapillary venules in vivo with resistance measurements and with… CONTINUE READING

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