Beta-adrenergic signals regulate cardiac differentiation of mouse embryonic stem cells via mitogen-activated protein kinase pathways.

@article{Yan2011BetaadrenergicSR,
  title={Beta-adrenergic signals regulate cardiac differentiation of mouse embryonic stem cells via mitogen-activated protein kinase pathways.},
  author={Lihui Yan and Zhuqing Jia and Jingjing Cui and Hongtao Yang and Huang-Tian Yang and Yongzhen Zhang and Chunyan Zhou},
  journal={Development, growth & differentiation},
  year={2011},
  volume={53 6},
  pages={772-9}
}
As embryonic stem cell-derived cardiomyocytes (ESC-CMs) have the potential to be used in cell replacement therapy, an understanding of the signaling mechanisms that regulate their terminal differentiation is imperative. In previous studies, we discovered the presence of adrenergic and muscarinic receptors in mouse embryonic stem cells (ESCs). However, little is known about the role of these receptors in cardiac differentiation and development, which is critically important in cardiac physiology… CONTINUE READING
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