Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

@article{Emrick2010BetaadrenergicregulatedPO,
  title={Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.},
  author={Michelle A Emrick and Martin Sad{\'i}lek and Keiichi Konoki and William A. Catterall},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 43},
  pages={18712-7}
}
Ca(V)1 channels initiate excitation-contraction coupling in skeletal and cardiac muscle. During the fight-or-flight response, epinephrine released by the adrenal medulla and norepinephrine released from sympathetic nerves increase muscle contractility by activation of the β-adrenergic receptor/cAMP-dependent protein kinase pathway and up-regulation of Ca(V)1 channels in skeletal and cardiac muscle. Although the physiological mechanism of this pathway is well defined, the molecular mechanism and… CONTINUE READING

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