Beta-adrenergic receptors in ischemic and nonischemic canine myocardium: relation to ventricular fibrillation and effects of pretreatment with propranolol and hexamethonium.

@article{Ohyanagi1988BetaadrenergicRI,
  title={Beta-adrenergic receptors in ischemic and nonischemic canine myocardium: relation to ventricular fibrillation and effects of pretreatment with propranolol and hexamethonium.},
  author={Mitsumasa Ohyanagi and Yoshinobu Matsumori and Takanori Iwasaki},
  journal={Journal of cardiovascular pharmacology},
  year={1988},
  volume={11 1},
  pages={
          107-14
        }
}
To explore possible roles of the sympathetic nervous system (especially the beta-adrenergic receptor and cAMP system) in the pathogenesis of ventricular fibrillation (VF), the authors examined changes in the number of myocardial beta-adrenergic receptors and the cAMP level in animals showing VF after experimental induction of myocardial ischemia. In animals that developed VF approximately 15 min after coronary ligation, the ischemic myocardium had a significantly larger number of beta… CONTINUE READING
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