Beta-adrenergic receptors and isoproterenol-stimulated potassium transport in erythrocytes from normal and hypothyroid turkeys. Quantitative relation between receptor occupancy and physiologic responsiveness.

We have previously reported that in hypothyroid turkeys the number of beta-adrenergic receptors in intact erythrocytes is reduced by approximately 50% without any changes in the affinity of the receptor for the agonist, isoproterenol. In view of the physiological action of the catecholamines to stimulate bidirectional ion fluxes in these cells, we have now… (More)