Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart.

@article{Morisco2001BetaadrenergicCH,
  title={Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart.},
  author={Carmine Morisco and David C. Zebrowski and Dorothy E. Vatner and Stephen F. Vatner and Junichi Sadoshima},
  journal={Journal of molecular and cellular cardiology},
  year={2001},
  volume={33 3},
  pages={561-73}
}
Myocardial beta-adrenergic receptors (beta -ARs) consist of beta(1)- and beta(2)-subtypes, which mediate distinct signaling mechanisms. We examined which beta-AR subtype mediates cardiac hypertrophy. The beta(2)-subtype is predominant in neonatal rat cardiac myocytes (beta(1), 36%vbeta(2), 64%), while the beta(1)-subtype predominates in the adult rat heart (59%v 41%). Stimulation of cultured cardiac myocytes in vitro with isoproterenol (ISO), an agonist for beta(1)- and beta(2)-ARs, caused… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

Similar Papers

Loading similar papers…