Beta-adrenergic adaptation in paediatric idiopathic dilated cardiomyopathy.

  title={Beta-adrenergic adaptation in paediatric idiopathic dilated cardiomyopathy.},
  author={Shelley D. Miyamoto and Brian L Stauffer and Stephanie J. Nakano and Rebecca D Sobus and Karin R Nunley and Penny Nelson and Carmen C. Sucharov},
  journal={European heart journal},
  volume={35 1},
BACKGROUND Although the pathophysiology and treatment of adult heart failure (HF) are well studied, HF in children remains poorly understood. In adults, adrenergic receptor (AR)-mediated adaptation plays a central role in cardiac abnormalities in HF, and these patients respond well to β-blocker (BB) therapy. However, in children with HF, there is a growing body of literature suggesting a lack of efficacy of adult HF therapies. Due to these unanticipated differences in response to therapy and… CONTINUE READING


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