Beta Receptor Blockade Potentiates the Antiarrhythmic Actions of d‐Sotalol on Reentrant Ventricular Tachycardia in a Canine Model of Myocardial Infarction

  title={Beta Receptor Blockade Potentiates the Antiarrhythmic Actions of d‐Sotalol on Reentrant Ventricular Tachycardia in a Canine Model of Myocardial Infarction},
  author={John Kassotis and Roy Sauberman and Candido Cabo and Andrew L. Wit and James Coromilas},
  journal={Journal of Cardiovascular Electrophysiology},
Introduction: The importance of beta receptor blockade for the antiarrhythmic action of sotalol has not been completely elucidated. We determined how beta receptor blockade interacts with the effects of potassium channel blockade on reentrant circuits. 
Electrophysiologic Actions of d,l-Sotalol and GLG-V-13 in Ischemically Injured Canine Epicardium
A variable response of ischemically injured canine epicardial cells to action potential prolongation with GLG-V-13 and d,l-sotalol is demonstrated, facilitating localized reentry in vitro, despite a failure of the same drugs to facilitate reentrant tachycardia in vivo.
Regadenoson, a Novel Pharmacologic Stress Agent for Use in Myocardial Perfusion Imaging, Does Not Have a Direct Effect on the QT Interval in Conscious Dogs
Regadenoson at 5 and 10 μg/kg did not cause a significant change in HR or QT interval either during atrial pacing at 165 bpm or after administration of propranolol and atropine to prevent HR from changing or after treatment of dogs with hexamethonium to block autonomic ganglia.
  • C. Cabo
  • Biology, Medicine
  • 2022
In computer models of the ventricular action potential, the use of a combination of IKs activators and IKr and Ik1 blockers could result in APD prolongation that potentially maximizes anti-arrhythmic effects and minimizes pro-arrhinic effects.
Myeloid Cell Sirtuin-1 Expression Does Not Alter Host Immune Responses to Gram-Negative Endotoxemia or Gram-Positive Bacterial Infection
It is demonstrated that myeloid SIRT1 expression does not change mortality in gram-negative toxin-induced shock or gram-positive bacteremia, suggesting that therapeutic suppression of Sirtuin-1 may be done safely without suppression of myeloids cell-specific immune responses to severe bacterial infections.


Frequency‐Dependent Electrophysiologic Effects of d,1‐Sotalol and Quinidine and Modulation by Beta‐Adrenergic Stimulation
Frequency‐dependent electrophysiologic actions of oral quinidine and oral sotalol may be clinically important, but these properties and their modulation by beta‐adrenergic sympathetic stimulation have not been determined.
Action of sotalol on potential reentrant pathways and ventricular tachyarrhythmias in conscious dogs in the late postmyocardial infarction phase.
Sotalol differentially increases refractoriness in potential reentry circuits in ischemic myocardium as well as in the infarct zone, which is presumably related to prolongation of action potential duration.
Beta-adrenergic blocking property of dl-sotalol maintains class III efficacy in guinea pig ventricular muscle after isoproterenol.
The beta-adrenergic blocking property of dl-sotalol maintains APD prolongation and repolarizing outward current block during isoproterenol infusion in guinea pig ventricular muscle.
Effects of dofetilide, a class III antiarrhythmic drug, on various ventricular arrhythmias in dogs.
Dofetilide increased QT interval and showed negative chronotropic effect like that of other class III drugs, but was different in antiarrhythmic profiles from those of otherclass III agents such as D-sotalol, E-4031, and MS-551 in that it did not prevent the occurrence of ventricular fibrillation (VF) immediately after coronary reperfusion and had some antiarrHythmic effects on digitalis arrhythmia.
Electrophysiologic effects of E-4031, a class III antiarrhythmic agent, on re-entrant ventricular arrhythmias in a canine 7-day-old myocardial infarction model.
Results demonstrated that E-4031 effectively prevented the induction of re-entrant ventricular tachycardia in canine myocardial infarction model, and suggested that E.4031 rendered re-ENTrant circuits inexcitable by marked ERP prolongation in both normal and infarct zones.
Frequency Dependent Effects of d‐Sotalol and Amiodarone on the Action Potential Duration of the Human Right Ventricle
D‐sotalol, a nonselective potassium channel blacker, has reverse use‐dependent effects on the human ventricular APD, while amiodarone with greater potassium channel selectivity, has equal ability to prolong the ventricularAPD at fast and slow heart rates.