Beta-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrPSc.

@article{KhaliliShirazi2007BetaPrPFO,
  title={Beta-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrPSc.},
  author={Azadeh Khalili-Shirazi and Maria Kaisar and Gary Mallinson and Samantha L. Jones and Daljit Bhelt and Carol A. Fraser and A. R. Clarke and Simon H. Hawke and Graham S. Jackson and John Collinge},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1774 11},
  pages={1438-50}
}
Prion diseases are associated with accumulation of strain-dependent biochemically distinct, disease-related isoforms (PrP(Sc)) of host-encoded prion protein (PrP(C)). PrP(Sc) is characterised by increased beta-sheet content, detergent insolubility and protease resistance. Recombinant alpha-PrP adopts a PrP(C)-like conformation, while beta-PrP conformationally resembles PrP(Sc), to these we raised 81 monoclonal antibodies in Prnp(0/0) mice. The N-terminal residues 91-110 are highly immunogenic… CONTINUE READING

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