Beta-N-methylamino-L-alanine. Chronic oral administration is not neurotoxic to mice.

  title={Beta-N-methylamino-L-alanine. Chronic oral administration is not neurotoxic to mice.},
  author={Thomas L. Perry and Catherine Racicot Bergeron and Alexander Biro and Shirley Hansen},
  journal={Journal of the neurological sciences},
  volume={94 1-3},
Repeated dietary consumption of the neurotoxic amino acid beta-N-methylamino-L-alanine (BMAA), found in the seeds of Cycas circinalis, has been postulated as causing both amyotrophic lateral sclerosis (ALS) and the parkinsonism-dementia syndrome (PD) that were formerly very prevalent among the indigenous people of the Marianas Islands. Cynomolgus monkeys fed BMAA have been reported to develop behavioral and neuropathological changes like those found in human ALS. We gave large amounts of BMAA… CONTINUE READING


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