Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code.

  title={Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code.},
  author={Kaoru Sakabe and Zihao Wang and Gerald W. Hart},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 46},
Dynamic posttranslational modification of serine and threonine residues of nucleocytoplasmic proteins by β-N-acetylglucosamine (O-GlcNAc) is a regulator of cellular processes such as transcription, signaling, and protein-protein interactions. Like phosphorylation, O-GlcNAc cycles in response to a wide variety of stimuli. Although cycling of O-GlcNAc is catalyzed by only two highly conserved enzymes, O-GlcNAc transferase (OGT), which adds the sugar, and β-N-acetylglucosaminidase (O-GlcNAcase… CONTINUE READING
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