Beta-Catenin Regulated ALDH1A1 is a Target in Ovarian Cancer Spheroids

  title={Beta-Catenin Regulated ALDH1A1 is a Target in Ovarian Cancer
  author={Salvatore Condello and Cynthia A. Morgan and Sarbajeet Nagdas and Liyun Cao and John J. Turek and Thomas D. Hurley and Daniela Elena Matei},
Cancer cells form three-dimensional (3D) multicellular aggregates (or spheroids) under non-adherent culture conditions. In ovarian cancer (OC), spheroids serve as a vehicle for cancer cell dissemination in the peritoneal cavity, protecting cells from environmental stress-induced anoikis. To identify new targetable molecules in OC spheroids, we investigated gene expression profiles and networks upregulated in 3D vs traditional monolayer culture conditions. We identified ALDH1A1, a cancer stem… CONTINUE READING