Beta-Catenin Is Vital for the Integrity of Mouse Embryonic Stem Cells

@inproceedings{Raggioli2014BetaCateninIV,
  title={Beta-Catenin Is Vital for the Integrity of Mouse Embryonic Stem Cells},
  author={A. Raggioli and Dirk Junghans and Stefan Rudloff and Rolf Kemler},
  booktitle={PloS one},
  year={2014}
}
β-Catenin mediated Wnt-signaling is assumed to play a major function in embryonic stem cells in maintaining their stem cell character and the exit from this unique trait. The complexity of β-catenin action and conflicting results on the role of β-catenin in maintaining the pluripotent state have made it difficult to understand its precise cellular and molecular functions. To attempt this issue we have generated new genetically modified mouse embryonic stem cell lines allowing for the deletion… CONTINUE READING

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