Beta-Blocker Selectivity at Cloned Human Beta1- and Beta2-Adrenergic Receptors

@article{Smith2004BetaBlockerSA,
  title={Beta-Blocker Selectivity at Cloned Human Beta1- and Beta2-Adrenergic Receptors},
  author={Carol Smith and Milt Teitler},
  journal={Cardiovascular Drugs and Therapy},
  year={2004},
  volume={13},
  pages={123-126}
}
Summary. [...] Key Method Bisoprolol, atenolol, propranolol, betaxolol, metoprolol, carvedilol, and ICI 118, 551 were compared for their beta-receptor selectivity using membranes prepared from recombinant cells selectively expressing human beta2 and beta1 receptors. Bisoprolol was found to have the highest selectivity for the beta1 receptor, displaying a beta2//beta1 ratio of 19 (a 19-fold higher affinity for the beta receptor than for the beta2 receptor). Atenolol, metoprolol, and betaxolol displayed lower…Expand
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