Beta 3-adrenergic receptor gene polymorphism is not a major genetic determinant of obesity and diabetes in Japanese general population.

@article{Yuan1997Beta3R,
  title={Beta 3-adrenergic receptor gene polymorphism is not a major genetic determinant of obesity and diabetes in Japanese general population.},
  author={X J Yuan and Kazuya Yamada and Kaneki Koyama and Fumito Ichikawa and Shuichi Ishiyama and Ai Koyanagi and Wasaku Koyama and Kenji Nonaka},
  journal={Diabetes research and clinical practice},
  year={1997},
  volume={37 1},
  pages={1-7}
}
To assess the contribution of a replacement of Trp at codon 64 of beta 3-adrenergic receptor by Arg to fat distribution and metabolic disturbances in Japanese general population, we examined the missense mutation in 1122 persons consisting of 817 men aged 50.0 +/- 8.9 years and 305 women aged 50.8 +/- 8.5 years in Kyushu, Japan. The incidence of Arg64 allele was 0.21; no age-dependent decrease of the allele frequency was observed, suggesting that the mutation was not associated with early… CONTINUE READING

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