Beta-2 microglobulin in ESRD: an in-depth review.

  title={Beta-2 microglobulin in ESRD: an in-depth review.},
  author={James F. Winchester and Jamie A Salsberg and Nathan W. Levin},
  journal={Advances in renal replacement therapy},
  volume={10 4},
Beta-2 microglobulin is the most widely studied low-molecular-weight protein in end-stage renal disease. It is known to cause dialysis-related amyloidosis (DRA), by virtue of its retention when renal function fails, its deposition in tissues, its aggregation into fibrils, and its ability to become glycosylated. The onset of DRA may be protracted by the use of noncellulosic membranes, especially when high-volume hemodiafiltration is used in the treatment of renal failure. Adsorptive methods have… CONTINUE READING


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