Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses.

@article{Brodde2008Beta1AB,
  title={Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses.},
  author={O E Brodde},
  journal={Pharmacology & therapeutics},
  year={2008},
  volume={117 1},
  pages={1-29}
}
  • O E Brodde
  • Published 2008 in Pharmacology & therapeutics
Beta-1 and beta-2 adrenoceptors (AR) play a pivotal role in regulation of the activity of the sympathetic nervous system and agonists and antagonists at both beta AR subtypes are frequently used in treatment of cardiovascular diseases. Both beta-1 and beta-2 AR genes have several polymorphisms that encode different amino acids. This review summarizes new insights into the functional importance of these polymorphisms, as well as their relationship to cardiovascular diseases and their impact on… CONTINUE READING