Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

@article{Bristow1986Beta1A,
  title={Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.},
  author={Michael R. Bristow and Robert Ginsburg and Victor A. W. M. Umans and Michael Fowler and Wayne Minobe and Randall Rasmussen and Pauline H. Zera and Ronald Menlove and Pankaj Shah and Stuart Jamieson},
  journal={Circulation research},
  year={1986},
  volume={59 3},
  pages={297-309}
}
We used radioligand binding techniques and measurement of beta-agonist-mediated positive inotropic responses in isolated cardiac tissue to examine beta-adrenergic-receptor subpopulations in nonfailing and failing human left and right ventricular myocardium. In tissue derived from 48 human hearts the receptor subtypes identified in nonfailing ventricle by radioligand binding were beta 1 (77%) and beta 2 (23%), with no evidence of an "atypical" beta-adrenergic receptor. In failing left ventricle… CONTINUE READING
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