Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis.

  title={Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis.},
  author={J. W. Dennis and Suzanne Lafert{\'e} and C G Waghorne and Martin L. Breitman and Robert S. Kerbel},
  volume={236 4801},
Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and beta 1-6-linked branching of complex-type asparagine (Asn)-linked oligosaccharides (that is, -GlcNAc beta 1-6Man alpha 1-6Man beta 1-). However, little is known about the relevant glycoproteins or how these transformation-related changes in oligosaccharide biosynthesis may affect the malignant phenotype. Here it is reported that a cell surface… CONTINUE READING
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