Beta-1,4-galactosylation of N-glycans is a complex process.

  title={Beta-1,4-galactosylation of N-glycans is a complex process.},
  author={Koji Furukawa and Toshiro Sato},
  journal={Biochimica et biophysica acta},
  volume={1473 1},
Most beta-1,4-galactosyltransferase (beta-1,4-GalT)-knockout mice die after birth. Although several defects were found transiently in these animals, the primary cause of death is obscure. Not only beta-1,4-linked galactose residues on N-glycans, but also beta-1, 4-GalT activities were found in some of the tissues. Recently, five human genes which encode beta-1,4-GalTs have been cloned, and the possible presence of such novel beta-1,4-GalTs in mice is considered to bring about survival of the… CONTINUE READING

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