Bet-hedging and epigenetic inheritance in bacterial cell development.

  title={Bet-hedging and epigenetic inheritance in bacterial cell development.},
  author={Jan-Willem Veening and Eric Jonathan Stewart and Thomas W. Berngruber and François Taddei and Oscar P. Kuipers and Leendert W Hamoen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 11},
Upon nutritional limitation, the bacterium Bacillus subtilis has the capability to enter the irreversible process of sporulation. This developmental process is bistable, and only a subpopulation of cells actually differentiates into endospores. Why a cell decides to sporulate or not to do so is poorly understood. Here, through the use of time-lapse microscopy, we follow the growth, division, and differentiation of individual cells to identify elements of cell history and ancestry that could… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 153 extracted citations


Publications referenced by this paper.
Showing 1-10 of 41 references

Rational design of memory in eukaryotic cells

  • CM Ajo-Franklin
  • Genes Dev 21:2271–2276
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…