Bet-hedging and epigenetic inheritance in bacterial cell development.

@article{Veening2008BethedgingAE,
  title={Bet-hedging and epigenetic inheritance in bacterial cell development.},
  author={Jan-Willem Veening and Eric Jonathan Stewart and Thomas W. Berngruber and François Taddei and Oscar P. Kuipers and Leendert W Hamoen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 11},
  pages={4393-8}
}
Upon nutritional limitation, the bacterium Bacillus subtilis has the capability to enter the irreversible process of sporulation. This developmental process is bistable, and only a subpopulation of cells actually differentiates into endospores. Why a cell decides to sporulate or not to do so is poorly understood. Here, through the use of time-lapse microscopy, we follow the growth, division, and differentiation of individual cells to identify elements of cell history and ancestry that could… CONTINUE READING

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Rational design of memory in eukaryotic cells

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