Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions.

@article{Kunzelmann2009BestrophinAT,
  title={Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions.},
  author={Karl Kunzelmann and Patthara Kongsuphol and Fadi Aldehni and Yuemin Tian and Jiraporn Ousingsawat and Richard Warth and Rainer Schreiber},
  journal={Cell calcium},
  year={2009},
  volume={46 4},
  pages={233-41}
}
In the past, a number of candidates have been proposed to form Ca(2+) activated Cl(-) currents, but it is only recently that two families of proteins, the bestrophins and the TMEM16-proteins, recapitulate reliably the properties of Ca(2+) activated Cl(-) currents. Bestrophin 1 is strongly expressed in the retinal pigment epithelium, but also at lower levels in other cell types. Bestrophin 1 may form Ca(2+) activated chloride channels and, at the same time, affect intracellular Ca(2+) signaling… CONTINUE READING