Bestatin Induces Specific Changes in Trypanosoma cruzi Dipeptide Pool

  title={Bestatin Induces Specific Changes in Trypanosoma cruzi Dipeptide Pool},
  author={Andrea Trochine and Darren John Creek and Paula Faral-Tello and Michael P. Barrett and Carlos Robello},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={2921 - 2925}
ABSTRACT Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases. 
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