Best practices for SNV and methylation calling from bisulfite sequencing data

Abstract

The advent of high-throughput sequencing techniques, together with<lb>bisulfite treatment of the DNA, allows for genome methylation profiling at a<lb>single cytosine resolution. Some modern tools, as MethylExtract [1], are also<lb>able to detect variation (SNVs) using the same bisulfite sequencing library,<lb>which is crucial for many downstream analyses… (More)

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