Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-β from induced inflammasomes.

@article{Stierle2011BerkeleyonesAR,
  title={Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-β from induced inflammasomes.},
  author={Donald B. Stierle and Andrea A Stierle and Brianna Patacini and Kyle McIntyre and Teri Alyn Girtsman and Erin S. Bolstad},
  journal={Journal of natural products},
  year={2011},
  volume={74 10},
  pages={2273-7}
}
The Berkeley Pit, an acid mine waste lake, is a source of extremophilic microorganisms that produce interesting bioactive compounds. We have previously reported the isolation of berkeleydione (1), berkeleytrione (2), the berkeleyacetals, and the berkeleyamides from the Pit Lake fungus Penicillium rubrum. In this paper we report the isolation and characterization of berkeleyones A-C (4, 5, and 7) as well as previously described preaustinoid A (3) and A1(6) from this same fungus. These compounds… CONTINUE READING

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