Berberine targets assembly of Escherichia coli cell division protein FtsZ.

Abstract

The ever increasing problem of antibiotic resistance necessitates a search for new drug molecules that would target novel proteins in the prokaryotic system. FtsZ is one such target protein involved in the bacterial cell division machinery. In this study, we have shown that berberine, a natural plant alkaloid, targets Escherichia coli FtsZ, inhibits the… (More)
DOI: 10.1021/bi7018546

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