Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9.

@article{Ho2009BerberineSI,
  title={Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9.},
  author={Yung-Tsuan Ho and J. Yang and Tsai-Chung Li and J Lin and Jaung-Geng Lin and Kuang Chi Lai and C Y Ma and Wellington Gibson Wood and Jing-Gung Chung},
  journal={Cancer letters},
  year={2009},
  volume={279 2},
  pages={155-62}
}
There is increasing evidence that urokinase-type plasminogen activator (u-PA) and matrix metalloproteinases (MMPs) play an important role in cancer metastasis and angiogenesis. Inhibition of u-PA and MMPs could suppress migration and invasion of cancer cells. Berberine, one of the main constituents of the plant Rhizoma coptidis, is a type of isoquinoline alkaloid, reported to have anti-cancer effects in different human cancer cell lines. There is however, no available information on effects of… CONTINUE READING

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